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Biochemistry |
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Articles
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Biochemical and molecular biology studies are necessary to understand chemical interactions and molecular changes associated with several eye diseases. Major focus is given to characterize the molecular interactions responsible for various types of cataract, macular degeneration, glaucoma, etc. The department also aims to study the matrix biology where interactions of cells with various extracellular matrices are studied. The abnormal cell and matrix interaction is involved in the pathology of certain cataracts, glaucoma, and retinopathies. The department is equipped with UV-visible spectrophotometer, one dimension and two dimension gel electrophoresis systems, refrigerated high speed centrifuge, etc.
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| Projects: |
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| Completed projects : |
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| Sr No. |
Project Title |
Duration |
Year |
Agency |
| 1 |
Cytological, biochemical and pharmacological approach to dissolve Corticocapsular adhesions (CCA) |
3 year |
2006-2009 |
DST/SERC Division, New Delhi. |
| 2 |
Role of antiangiogenic factors in maintaining the avascularity of the human lens. |
3 year |
2008–2011 |
DRDO |
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| Publications: |
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| 1. Alapure BV, Praveen MR, Gajjar D, Vasavada AR, Rajkumar S, Johar K. |
Matrix metalloproteinase-9 activity in human lens epithelial cells of cortical, posterior subcapsular, and nuclear cataracts. J Cataract Refract Surg. 2008 Dec;34(12):2063-7. |
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| 2. Gajjar D, Jozwiak A, Swiezewska E, Alapure B, Parmar T, Johar K, Vasavada AR. |
Quantification of dolichol in the human lens with different types of cataracts. Mol Vis. 2009 Aug 11;15:1573-9. |
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| 3. Rajkumar S, Praveen MR, Gajjar D, Vasavada AR, Alapure B, Patel D, Kapur S. |
Activity of superoxide dismutase isoenzymes in lens epithelial cells derived from different types of age-related cataract. J Cataract Refract Surg. 2008 Mar;34(3):470-4. |
| 4. Alapure BV, Praveen MR, Gajjar DU, Vasavada AR, Parmar TJ, Arora AI |
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Matrix metalloproteinase-2 and -9 activities in the human lens epithelial cells and serum of steroid induced posterior subcapsular cataracts. Mol Vis. 2012;18:64-73.Epub 2012 Jan 11.
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